For more than a decade Kalki has been working for the social, political, legal and economic rights of the transgender people of India and been an active supporter of lgbtqi rights in India. In 2008, she found the organisation Sahodari Foundation ( Through Sahodari Foundation, Kalki has been transforming the lives of hundreds of transgender people across India.

Kalki contribution in Indian Supreme court verdict legally recognizing transgender people and subsequently directing the central and state governments to protect and take action for the welfare of the community has been an important milestone victory of her activism. She was one of the few activists who lobbied strongly among the judiciary for social justice.